朱力

教授,博士生导师

 

 

   江苏省苏州市工业园区仁爱路199703509

   苏州大学唐仲英血液研究中心

   电话:0512-65880877-3509

   传真:0512- 65882122

     Email: lizhusong@yahoo.com

 

 

教育背景:

 

1978-1964          吉林大学  英语医学专业  学士

1986-1989          吉林大学  免疫学专业  硕士

1992-1998          吉林大学/加州大学/渥太华大学联合培养  免疫学专业  博士

1999-2002          美国杰佛逊大学 生化专业  博士后

 

工作经历:

 

2003-2008          美国宾夕法尼亚大学大学  高级研究员

2008-2009          美国拜尔制药公司  主管研究员

2009-至今              苏州大学唐仲英血液学研究中心  特聘教授

 

研究领域及内容/临床专攻领域及内容:

 

l  血小板活化和血栓形成的信号传递

l  血管新生和动脉粥样硬化

l  心脑血管疾病临床急性血栓事件的机制与干预

l  巨核细胞分化和血小板发育以及干细胞体内通路的研究

 

团队成员:

 

任丽洁,硕士,助理研究员

卢穹宇,硕士,助理研究员

刘晓辉,博士研究生

  飞,博士研究生

卢穹宇,博士研究生

  招,硕博连读研究生

  强,硕士研究生

易文秀,硕士研究生

  健,硕士研究生

胡淑鸿,硕士研究生

  婷,硕士研究生

徐冬洲,硕士研究生

 

代表性成果:

 

研究论文:

 

1.     Qiongyu Lu, Ningzheng Dong, Qi Wang, Wenxiu Yi, Yuxin Wang, Shengjie Wang, Haibo Gu, Xin Zhao, Xiaorong Tang, Boquan Jin, Qingyu Wu, Lawrence F. Brass, and Li Zhu. Increased levels of Plasma Soluble Sema4D in Patients with Heart Failure. PloS One 2013;8(5)e64265.

 

2.     Peipei Mou, Zhao Zeng, Qiang Li, Xiaohui Liu, Xiaoran Xin, Kenneth M. Wannemacher, Changgeng Ruan, Renhao Li, Lawrence F. Brass and Li Zhu. Identification of a Calmodulin-binding Domain in Sema4D that Regulates its Exodomain Shedding in Platelets. Blood 2013;121:4221-4230.

 

3.     Kenneth M. Wannemacher*, Li Zhu*, Hong Jiang, Karen P. Fong, Timothy J. Stalker, Dooyoung Lee, Anh N. Tran, Keith Neeves, Sean Maloney, Atsushi Kumanogoh, Hitoshi Kikutani, Daniel A. Hammer, Scott L. Diamond and Lawrence F. Brass. Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D. Blood. 2010;116:5705-5715.

 

4.     Li Zhu, Timothy J. Stalker, Karen P. Fong, Hong Jiang, Anh Tran, Irene Crichton, Eric K. Lee, Keith B. Neeves, Sean F. Maloney, Hitoshi Kikutani, Atsushi Kumanogoh, Ellen Pure, Scott L. Diamond and Lawrence F. Brass.  Disruption of sema4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis. Arterioscler Thromb Vasc Biol 2009; 29:1039-1045.

 

5.     Li Zhu, Wolfgang Bergmeier, Jie Wu, Hong Jiang, Timothy J. Stalker, Marcin Cieslak, Ran Fan, Laurence Boumsell, Atsushi Kumanogoh, Hitoshi Kikutani, Luca Tamagnone, Denisa D. Wagner, Marcos E. Milla and Lawrence F. Brass. Regulated surface expression and shedding support a dual role for semaphorine 4D in platelet responses to vascular injury. Proc Natl Acad Sci 2007;104:1621-1626.

 

6.     Suzanne Paradis, Dana B. Harrar, Yingxi Lin, Alex C. Koon, Jessica L. Hauser, Eric C. Griffith, Li Zhu, Lawrence F. Brass, Chinfei Chen, and Michael E. Greenberg. An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development. Neuron 2007;53:217-232.

 

7.     Xiangdong Wu*, Li Zhu *, Assaf Zilbering, Mahadev Kalyankar, Susie Hong, Junli Yao and Barry J. Goldstein. Hyperglycemia potentiates H2O2 production in adipocytes and enhances insulin signal transduction: potential role for the oxidative inhibition of thiol-sensitive protein-tyrosine phosphatases. Antioxid. Redox Signal 2005;7:526-537. *co-first authors

 

8.     Li Zhu, Assaf Zilbering, Xiangdong Wu, Mahadev Kalyankar, Jeffrey I. Joseph, Serge Jabbour, Wasim Deeb and Barry J. Goldstein: Use of an anaerobic environment to preserve the endogenous activity of protein-tyrosine phosphatases isolated from intact cells. FASEB J 2001;15:1637-1639.

 

9.     Barry J. Goldstein, Li Zhu(朱力), Richard Hager, Assaf Zilbering, Yanjie Sun and Vincent JB: Enhancement of post-receptor insulin signaling by trivalent chromium in hepatoma cells may involve differential inhibition of specific protein-tyrosine phosphatases. Journal of Trace Elements in Experimental Medicine 2001;14:393-404.

 

10.  Mahadev Kalyankar, Assaf Zilbering, Li Zhu, and Barry J. Goldstein: Insulin-stimulated generation of hydrogen peroxide reversibly inhibits PTP1B and enhances the early insulin action cascade. J Biol Chem 2001;276:21938-21942.

 

11.  Li Zhu, Nick Ohan, Yehenew Agazie, Cathy Cummings, Sahar Farah and X. Johne Liu: Molecular cloning and characterization of xenopus insulin-like growth factor-1 (IGF-1) receptor: Its role in mediating xenopus oocyte maturation and expression during embryogenesis. Endocrinology 1998;139:949-959.

 

12.  Cathy Cummings, Li Zhu, Alexander Sorisky and X. Johne Liu: A peroxovanadium compound induces xenopus oocyte maturation: Inhibition by a neutralizing anti-insulin receptor antibody. Dev Biol 1996;175:338-346.

 

13.  Xingquan Liu, Alexander Sorisky, Li Zhu and Tony Pawson: Molecular Cloning of an amphibian IRS-l cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced xenopus oocyte maturation. Mol Cell Biol 1995;15:3563-3570.

 

14.  Victoria A. Mancuso, Thomas J. Hope, Li Zhu, David Derse, Tom Philips and Tristram G. Parslow: Posttranscriptional effector domains in the Rev proteins of feline immunodeficiency virus and equine infectious anemia virus. J Virol 1994; 68:1998-2001.

 

15.  Li Zhu, Thomas G. Hope, Jackson Hall, Anthony Davies, Michael Stern, Ursula Muller-Eberhard, Robert Stern and Tristram G. Parslow: Molecular cloning of a mammalian hyaluronidase reveals identity with hemopexin, a serum heme-binding protein. J Biol Chem 1994;269:32092-32097.

 

著书和文献综述:

 

1.     Lawrence F. Brass, Li Zhu, and Timothy J. Stalker. Novel therapeutic targets at the platelet vascular interface. Arterioscler Thromb Vasc Biol 2008;28:s43-50.

 

2.     Lawrence F. Brass, Timothy J. Stalker, Li Zhu, and Donna S. Woulfe. Signal transduction during platelet plug formation. In A. D. Michelson (ed), Platelets Academic Press, 2007; p319-357.

 

3.     Lawrence F. Brass, Li Zhu, and Timothy J. Stalker. Minding the gaps to promote thrombus growth and stability. J Clin Invest 2005;115:3385-3392.

 

4.     Barry J. Goldstein, Mahadev Kalyankar, Xiangdong Wu, Li Zhu, Hiroshima Motoshima. Role of insulin-induced reactive oxygen species in the insulin signaling pathway. Antioxid Redox Signal 2005;7(7-8):1021-31.

 

5.     Lawrence F. Brass, Timothy J. Stalker, Li Zhu, Boxun Lu, Donna S. Woulfe, Nicholas Prevost. Boundary events: contact-dependent and contact-facilitated signaling between platelets. Semin Thromb Hemost 2004;30(4):399-410.

 

6.     Li Zhu and Barry J. Goldstein. Use of an anaerobic chamber environment for the assay of endogenous cellular protein-tyrosine phosphatase activities. Biol Proced Online, 2002, 4:1-9.

 

荣誉称号:

 

2009江苏省六大高峰人才

2010江苏省优势学科建设《血液转化医学-血栓与心脑血管疾病》研究方向学术带头人

2011苏州市紧缺人才

2011江苏省血液转化医学创新团队学术骨干

 

主要学术任职:

 

中国病理生理学会动脉粥样硬化专业委员会               副主任委员

全国专业标准化技术委员会                                      委员

国际血栓与出凝血学会、美国血液学会                      会员

中国动脉硬化杂志                                                   编委

 

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