教育背景：

1982年-1987年 河北医科大学 医学专业 学士
1991年-1994年 河北医科大学 内科学专业 硕士
1997年-2002年 日本山梨大学医学院 生物化学专业 博士
2002年-2005年 美国新泽西医学院 分子生物学专业 博士后

工作经历：

2005年-2023年 美国Temple大学血栓研究中心 助理教授，副教授
2009年-至今 苏州大学唐仲英血液学研究中心 教授，博士生导师

研究领域：

1． 血栓形成的氧化还原调控机制
（1）应用二硫键异构酶家族的基因敲除小鼠，确定对血小板和凝血系统发挥正性和负性作用的二硫键异构酶，解析该家族对动脉和静脉血栓形成的平衡调控及氧化还原信号网络（redox signaling network）。
（2）鉴定血小板和凝血系统的主要蛋白的关键性功能二硫键，应用巯基组学技术，研究静息与活化状态巯基-二硫键交换的动态过程及调控机制。
（3）研发靶向二硫键异构酶的抗血栓药物。
2．二硫键异构酶家族的生理作用
（1）应用二硫键异构酶家族的基因敲除小鼠，认识该家族在胚胎发育、骨髓造血、糖脂代谢、精子生成等基本生命过程中的关键作用。
（2）应用多种组学技术，研究二硫键异构酶家族在维持不同细胞内质网蛋白质稳态中的功能，鉴定其调控底物和作用的半胱氨酸位点。
3. 血浆激肽释放酶-激肽系统（内源性凝血系统）在固有免疫中的作用
研究该系统在固有免疫和脓毒症中的作用，建立新的治疗内毒素血症的靶点和干预途径。

团队成员：

阳艾珍，博士，副研究员
赵珍珍，博士，博士后
博士研究生: 陈凤梧，张雅琼，禄悦，严小峰，何超
硕士研究生: 孙凯飞, 卜嘉楠, 王宇灿，郭润林，徐琳亚，孙凯威，刘硕，彭美男，程艺馨，陈旭阳，张琦

代表性成果：

.Yue Lu*, Aizhen Yang, Zhenzhen Zhao, Yue Han, Depei Wu*, Yi Wu*. Protein disulfide isomerase is essential for osteoblast differentiation in mice. Communications Biology. 2025, DOI:10.1038/s42003-025-07824-3.
2.Chao He, Aizhen Yang, Keyu Lv, Yuxin Zhang, Zhenzhen Zhao, Yi Lu, Chao Fang, Yue Han, Depei Wu, Miao Jiang, Jingyu Zhang*, Yi Wu*. Thiol isomerase ERp18 enhances platelet activation and arterial thrombosis. Research and Practice in Thrombosis and Hemostasis 2025. DOI:10.1016/j.rpth.2025.102706
3.Fengwu Chen*, Aizhen Yang, Yue Lu, Yuxin Zhang, Jingyu Zhang, Jianan Bu, Runlin Guo, Yue Han, Depei Wu*, Yi Wu*. Identification of the differential transport pathways of saturated and unsaturated fatty acid esters in hepatocytes. Nature Communications 2025;16:1344
4.Zhenzhen Zhao*, Yucan Wang, Aizhen Yang, Xiaofeng Yan, Yi Lu, Meinan Peng, Yue Han, Chao Fang, Depei Wu, Yi Wu*. A novel role for thioredoxin-related transmembrane protein TMX4 in platelet activation and thrombus formation. Journal of Thrombosis and Hemostasis, 2025;23(1):277-292.
5.Kaifei Sun, Yaqiong Zhang, Aizhen Yang, Yuxin Zhang, Zhenzhen Zhao, Xiaofeng Yan, Yi Lu, Yue Han, Depei Wu, Freda Passam, Jingyu Zhang*, Yi Wu*. Extracellular thiol isomerase ERp5 regulates integrin αIIbβ3 activation by inhibition of fibrinogen binding. Platelets, 2025; 36(1): 2455743
6.Chao He, Aizhen Yang*, Yuxin Zhang, Zhenzhen Zhao, Yi Lu, Jingyu Zhang, Yi Wu*. A novel role for protein disulfide isomerase ERp18 in venous thrombosis. Thrombosis Journal. 2024;22(1):110
7.Zhenzhen Zhao*, Yixin Cheng, Yaqiong Zhang, Meinan Peng, Yue Han, Depei Wu, Aizhen Yang, Yi Wu*. Transmembrane thiol isomerase TMX1 counterbalances the effect of ERp46 to inhibit platelet activation and integrin αIIbβ3 function. Research and Practice in Thrombosis and Hemostasis 2024;8(5):102524.
8.Aizhen Yang, Li Lin, Jingyu Zhang, Yi Wu, Zhenzhen Zhao*. A novel role of ERp72 in the pathogenesis of autoantibody-induced arthritis. Scandinavian Journal of Rheumatology 2024 Jul 8:1-9.
9.Yaqiong Zhang*, Aizhen Yang, Zhenzhen Zhao*, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, Yi Wu*. Protein disulfide isomerase is essential for spermatogenesis in mice. JCI Insight 2024;9(12);e177743.
10.Liang Gao, Chao He, Aizhen Yang, Haibin Zhou, Qingxian Lu, Raymond B. Birge, Yi Wu*. Receptor tyrosine kinases Tyro3, Axl, and Mer differentially contribute to antibody-induced arthritis. Cell Communication and Signaling 2023;21(1):195. (*corresponding author).
11.Yi Wu*. Seaweed fucoidan targeting platelet GPIbα: Hope from the ocean. Journal of Thrombosis and Haemostasis 2023;21(5):1100-1101. (Commentary)
12.Y Wu*, Yi Lu, Jingyu Zhang*. Thrombin generation assay: the present and future. Blood Coagulation & Fibrinolysis 2023;34(1):1-7 (*corresponding author).
13.Yongxue Zhang, Qi Miao, Sai Shi, Han Hao, Xinmeng Li, Yakun Yang, Hailong An, Wei Zhang, Youzhen Kong, Xu Pang, Nikita Gamper, Yi Wu*, Hailin Zhang*, Xiaona Du*. Protein disulfide isomerase (PDI) modulation of TRPV1 controls heat hyperalgesia in chronic pain. Cell Reports 2022;39(1):110625. (*corresponding author).
14.Yuxin Zhang, Fengwu Chen, Aizhen Yang, Xiaoying Wang, Yue Han, Depei Wu, Yi Wu*, Jingyu Zhang*. The disulfide bond Cys2724-Cys2774 in the C-terminal cystine knot domain of von Willebrand factor is critical for its dimerization and secretion. Thrombosis Journal 2021;19(1):94.
15.Yi Wu. Plasmin taking contact system to inflame liver. Blood 2021;138(3):208-209. (Commentary)
16.Wu Y*, Essex DW*. Vascular thiol isomerases in thrombosis: The Yin and Yang. Journal of Thrombosis and Haemostasis.  2020;18(11):2780-2800. (*corresponding author, invited review)
17.B. Wang, X. Yan, A. Yang, Y. Lu, Y. Wu*. Plasma kallikrein contributes to ambient particulate matter-induced lung injury. Biochemical and Biophysical Research Communications, 2019;518(3):409-415.
18.Zhenzhen Zhao#*, Yi Wu#*, Junsong Zhou, Fengwu Chen, Aizhen Yang, David Essex*. The transmembrane protein disulfide isomerase TMX1 negatively regulates platelet responses. Blood. 2019;133(3):246-251. (#Equal first author, *corresponding author).
19.Junsong Zhou*, Aizhen Yang, Fengwu Chen, Zhenzhen Zhao, Katsue Suzuki-Inoue, Yukio Ozaki, and Raymond Birge, Yi Wu*. Growth arrest-specific gene 6 receptors, Tyro3, Axl, and Mer, differentially support platelet activation and thrombosis. Cell Communication and Signaling, 2018;16(1):98. (*corresponding author).
20.Yi Wu. The plasma contact system as a modulator of innate immunity. Current Opinion in Hematology 2018;25(5):389-394. (invited review)
21.David Essex*, Yi Wu*. Multiple Protein Disulfide Isomerases Support Thrombosis. Current Opinion of Hematology 2018;25(5):395-402. (*corresponding author, invited review)
22.Chen F, Zhao Z, Zhou J, Lu Y, Essex, DW, Wu Y*. Protein disulfide isomerase enhances tissue factor-dependent thrombin generation. Biochemical and Biophysical Research Communications. 2018;501(1):172-177.
23.B. Wang, A. Yang, Z. Zhao, C. He, Y. Liu, R.W. Colman, J. Dai, Y. Wu*. Plasma kallikrein-kininogen pathway is critical in the pathogenesis of colitis in mice. Frontiers in Immunology. 2018 Feb 6;9:21. doi: 10.3389/fimmu.2018.00021. (*corresponding author).
24.A. Yang, F. Chen, C. He, J. Zhou, Y. Lu, J. Dai, R.B. Birge, Y. Wu*. The pro-coagulant activity of apoptotic cells is mediated by interaction with Factor XII. Frontiers in Immunology, 2017,8:1188.
25.A. Yang, J. Zhou, B. Wang, R.W. Colman, J. Dai, W. Song, Y. Wu*. A critical role for plasma kallikrein in autoantibody-induced arthritis. FASEB Journal. 2017;31(12):5419-5431.
26.J. Zhou#, Y. Wu#*, F. Chen, L. Wang, L. Rauova, V.M. Hayes, M. Poncz, H. Li, T. Liu, J. Liu, D.W. Essex*. The disulfide isomerase ERp72 supports arterial thrombosis. Blood. 2017;130(6):817-828. (#Equal first author, *corresponding author).
27.A. Yang, Z. Xie, B. Wang, R.W. Colman, J. Dai, Y. Wu*. An essential role of high-molecular-weight kininogen in endotoxemia. Journal of Experimental Medicine. 2017;214(9):2649-2670.
28.J. Zhou#, Y. Wu#*, L. Wang, L. Rauova, V.M. Hayes, M. Poncz, D.W. Essex*. The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis. Journal of Clinical Investigation. 2015;125(12):4391-406. (#Equal first author, *corresponding author).
29.J. Nelson, Y. Wu,  X.H. Jiang,  R. Berretta,  S. Houser,  E. Choi,   J.F. Wang,   J. Huang, X.F. Yang, H. Wang. Hyperhomocysteinemia suppresses bone marrow CD34+/VEGFR2+ cells and inhibits progenitor cell mobilization and homing to injured vasculature - A role of β1 integrin in progenitor cell migration and adhesion. FASEB Journal 2015;29(7):3085-99.
30.Y. Wu. Contact pathway of coagulation and inflammation. Thrombosis Journal, 2015;13:17. (invited review)
31.X. Zhu, X. Zheng, Y. Wu*. Cleaved high molecular weight kininogen stimulates JNK/FOXO4/ MnSOD pathway for induction of endothelial progenitor cell senescence. Biochemical Biophysical Research Communications. 2014;450(4):1261-5.
32.Z. Xie, J. Dai, A. Yang, Y. Wu*. Role of bradykinin in the pathogenesis of anti-collagen antibodies-induced arthritis. Rheumatology 2014;53(7):1301-6.
33.A. Yang, J. Dai, Z. Xie, R. W. Colman, Q. Wu, R.B. Birge and Y. Wu. High molecular weight kininogen binds phosphatidylserine and opsonizes urokinase plasminogen activator receptor-mediated efferocytosis. Journal of Immunology 2014;192(9):4398-408.
34.L. Wang, Y. Wu*, J. Zhou, S.S. Ahmad, B. Mutus, N. Garbi, G. Hämmerling, J. Liu, and D.W. Essex*. Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin. Blood 2013;122(22):3642-50. (Equal first author, *corresponding author)
35.Y. Wu, S. Ahmad, J. Zhou, L. Wang, M.P. Cully, D.W. Essex. The disulfide isomerase ERp57 mediates platelet aggregation, hemostasis, and thrombosis. Blood 2012;119(7):1737-46.
36.J. Dai, A. Agelan, A. Yang, V. Zuluaga, D. Sexton, R.W. Colman, Y. Wu*. A role for activation of the kallikrein-kinin system in the synovial recruitment of endothelial progenitor cells in arthritis. Arthritis & Rheumatism 2012;64(11):3574-82.
37.J. Dai, X. Zhu, M.C. Yoder, Y. Wu*, R.W. Colman. Cleaved high molecular weight kininogen accelerates senescence of endothelial progenitor cells by induction of reactive oxygen species. Arteriosclerosis, Thrombosis and Vascular Biology 2011;31(4):883-889.(*corresponding author).
38.Y. Wu*, J. Dai, N.G. Schmuckler, M.C. Yoder, C.M. Overall, R.W. Colman. Cleaved kininogen inhibits endothelial progenitor cell differentiation via suppression of matrix metallopeptidase 2. Journal of Thrombosis and Haemostasis, 2010;8(1):185-93.(*corresponding author).
39.Y. Wu*, V. Rizzo, Y. Liu, I. Sainz, N. Schmuckler, R.W. Colman*. Kininostatin associates with caveolae and inhibits ?v?3 integrin activation in human umbilical vein endothelial cells. Arteriosclerosis, Thrombosis and Vascular Biology 2007;27(9):1968-75. (*corresponding author).
40.Y. Wu, N. Tibrewal, R.B. Birge. Phosphatidylserine recognition by phagocytes: a view to a kill. Trends in Cell Biology 2006;16(4):189-97. (Invited review)
41.Y. Wu, S. Singh, M.M. Georgescu, R.B. Birge. A role for Mer tyrosine kinase in ?v?5 integrin-mediated phagocytosis of apoptotic cells. Journal of Cell Science 2005;118(3):539-553.
42.Y. Wu, N. Asazuma, K. Satoh, T. Takafuta, Y. Yatomi, M.C. Berndt, and Y. Ozaki. Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase. Blood 2003;101(9):3469-3476.
43.Y. Wu, K. Inoue-Suzuki, K. Satoh, N. Asazuma, Y. Yatomi, M.C. Berndt, and Y. Ozaki. Role of Fc receptor ?-chain in platelet glycoprotein Ib-mediated signaling. Blood 2001;97(12):3836-3845.
44.Y. Wu, Y. Ozaki, K. Inoue, K. Satoh, T. Ohmori, Y. Yatomi, K. Owada. Differential activation and redistribution of c-Src and Fyn in platelets, assessed by MoAb specific for C-terminal tyrosine-dephosphorylated c-Src and Fyn. Biochimica et Biophysica Acta-Molecular Cell Research 2000;1497:27-36.

国家发明专利：

1. TMX1 的用途。专利号：ZL201811314417.X。武艺、赵珍珍、周俊松、孙凯飞。
2.单克隆抗体6C9G4 及其在制备治疗内毒素血症的药物中的应用。专利号：ZL201710323138.9。武艺、阳艾珍。
3.单克隆抗体C11C1 在制备治疗内毒素血症的药物中的应用。专利号：ZL.2017 10250546.6。武艺、阳艾珍、谢展利、王波。
4.一种脂多糖结合蛋白多肽及其制药用途。专利号：ZL 2016 1 0150319.1。武艺、阳艾珍、谢展利。
5.一种杂交瘤细胞及其产生的单克隆抗体和应用。专利号：ZL201410184173.3。武艺、周俊松、陈凤梧。

学术任职：

Co-chair, International Society of Thrombosis and Hemostasis-Scientific and Standardization subcommittee (ISTH-SSC) on contact system
Deputy Editor, Thrombosis Journal (2013 – present）
Editor, Cell Communication and Signaling (2017 – present)