Kesheng Dai, M.D., Ph.D.
199 Ren'ai Rd. Suzhou, Jiangsu 215123, P.R.China
Cyrus Tang Hematology Center, Soochow University
Phone: 86-512-65880877
Email: kdai@suda.edu.cn
Education:
1984-1988 M.D., Bengbu Medical College
1994-1996 M.S., Sunyat Sun Medical University
1999-2002 Ph.D., Soochow University
2002-2005 Postdoctoral Fellow, University of Illinois at Chicago, USA
Professional Experience:
1988-1999 Assistant/Lecturer/Associate professor, Bengbu Medical College
2005-2011 Professor//Principal Investigator, Beihang University
2011-Present Professor/Principal Investigator, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health
2019-Present Professor/Principal Investigator, Cyrus Tang Medical Institute, Soochow University
Research:
The goal of our laboratory is to understand the roles of platelets in thrombosis, hemostasis, and other major diseases. Specifically, we study 1) the regulatory mechanisms of platelet in thrombosis and hemostasis, 2) the regulatory mechanisms of platelet lifespan and related diseases, and 3) role of platelets in major diseases.
Investigators:
Staff
Rong Yan, Ph.D., Associate Investigator
Lili Zhao, Ph.D., Senior Research Associate
Chunliang Liu, Ph.D., Senior Research Associate
Renping Hu, Lab Manager
Postdoctoral Research Associate：Jingluan Tian
Graduate Students
Ph.D. Students: Weiling Xiao, Ningbo Pang, Xinxin Ge, Kangxi Zhou, Yueyue Sun, Muhammad Khan
Master Students: Suqin Zhang, Liuxia Yuan, Mengnan Yang, Yue Xia, Ying Hu, Chenglin Sun
Representative papers:
1. Chen M, Yan R, Zhou K, Li X, Zhang Y, Liu C, Jiang M, Ye H, Meng X, Pang N, Zhao L, Liu J, Xiao W, Hu R, Cui Q, Zhong W, Zhao Y, Zhu M, Lin A, Ruan C, Dai K. Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia. Proc Natl Acad Sci U S A 2018;115(45):E10682-91.
2. Zhao L, Liu J, He C, Yan R, Zhou K ,Cui Q, Meng X, Li X, Zhang Y, Nie Y, Zhang Y, Hu R, Liu Y, Zhao L, Chen M, Xiao W, Tian J, Zhao Y, Cao L, Zhou L, Lin A, Ruan C, Dai K. Protein kinase A determines platelet lifespan and survival by regulating apoptosis. Journal of Clinical Investigation 2017;127(12):4338-51.
3. Zhang Y, Zhang J, Yan R, Tian J, Zhang Y, Zhang J, Chen M, Cui Q, Zhao L, Hu R, Jiang M, Li Z, Ruan C, He S, Dai K. Receptor-interacting protein kinase 3 promotes platelet activation and thrombosis. Proc Natl Acad Sci U S A 2017;114(11):2964-69.
4. Liu L, Chen M, Zhao L, Zhao Q, Hu R, Zhu J, Yan R, Dai K. Ethanol Induces Platelet Apoptosis. Alcoholism: Clinical and Experimental Research 2017; 41(2): 291–298.
5. Zhao Q, Li M, Chen M, Zhou L, Zhao L, Hu R, Yan R, Dai K. Lovastatin induces platelet apoptosis. Environmental Toxicology and Pharmacology 2016;42:69-75.
6. Yan R, Chen M, Ma N, Zhao L, Cao L, Zhang Y, Zhang J, Yu Z, Wang Z, Xia L, Ruan C, Dai K. Glycoprotein Ibα clustering induces macrophage-mediated platelet clearance in the liver. Thrombosis and Haemostasis 2015;113(1):107-17.
7. Zhao L, Lu G, Zhao Q, Zhang M, Chen M, Zhang J, Dai K. Staurosporine Induces Platelet Apoptosis Through p38 Mitogen-Activated Protein Kinase Signaling Pathway. Clin Lab 2015;61(7):717-26.
8. Li J, Dai K, Wang Z, Cao L, Bai X, Ruan C. Platelet functional alterations in a Bernard-Soulier syndrome patient with filamin A mutation. J Hematol Oncol. 2015;8:79.
9. Wu Y, Dai J, Zhang W, Yan R, Zhang Y, Ruan C, Dai K. Arsenic trioxide induces platelet apoptosis. PLoS One 2014;9(1):e86445.
10. Zhang J, Chen M, Zhang Y, Zhao L, Yan R, Dai K. Carmustine induces platelet apoptosis. Platelets 2015;26(5):437-42
11. Li M, Wang Z, Ma T, Lu G, Yan R, Zhao L, Deng K, Dai K. Enhanced platelet apoptosis in chronic uremic patients. Renal Failure 2014;36:847-53.
12. Pan Y, Yago T, Fu J, Herzog B, McDaniel J, MehtaD'Souza P, Cai X, Ruan C, McEver J, West C, Dai K, Chen H, Xia L. Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets. Blood 2014;124(24):3656-65.
13. Shou LM, Zhang QY, Li W, Xie X, Chen K, Lian L, Li ZY, Gong FR, Dai KS, Mao YX, Tao M. Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of α2 integrin. Oncol Rep 2013;30(3):1059-66.
14. Zhang P, Du J, Zhao L, Wang X, Zhang Y, Yan R, Dai J, Liu G, Zhang F, Dai K. The role of intraplatelet reactive oxygen species in the regulation of platelet glycoprotein Ibα ectodomain shedding. Thrombosis Research 2013;132(6):696-701.
15. Zhao L, Zhang W, Chen M, Zhang J, Zhang M, Dai K. Aspirin induces platelet apoptosis. Platelets 2013;24(8):637-42.
16. Zhang W, Zhao L, Liu J, Du J, Yan R, Dai K. Role of 14-3-3ζ in Platelet Glycoprotein Ibα-von Willebrand Factor Interaction-Induced Signaling. International Journal of Molecular Sciences 2012;13:5364-74.
17. Zhang W, Zhao L, Liu J, Du J, Wang Z, Ruan C, Dai K. Cisplatin induces platelet apoptosis through the ERK signaling pathway. Thrombosis Research 2012;13:81-91.
18. Yan R, Mo X, Paredes AM, Dai K, Lanza F, Cruz MA, Li R. Reconstitution of the Platelet Glycoprotein Ib-IX Complex in Phospholipid Bilayer Nanodiscs. Biochemistry 2011;50(49):10598-606.
19. Zhang W, Liu J, Sun R, Zhao L, Du J, Ruan C, Dai K. Calpain Activator Dibucaine Induces Platelet Apoptosis. International Journal of Molecular Sciences 2011;12:2125-37.
20. Li S, Wang Z, Liao Y, Zhang W, Shi Q, Yan R, Ruan C, Dai K. The glycoprotein Ibalpha-von Willebrand factor interaction induces platelet apoptosis. Journal of Thrombosis and Haemostasis 2010;8:341-50.
21. Wang Z, Shi Q, Yan R, Liu G, Zhang W, Dai K. The role of calpain in the regulation of ADAM17-dependent GPIb ectodomain shedding. Archives of Biochemistry and Biophysics 2010;495:136-43.
22. Li S, Shi Q, Liu G, Zhang W, Wang Z, Wang Y, Dai K. Mechanism of platelet functional changes and the effects of anti-platelet agents on in vivo hemostasis under different gravity conditions. Journal of Applied Physiology 2010;108:1241-49.
23. Wang Z, Shi Q, Li S, Du J, Liu J, Dai K. Hyperthermia induces platelet apoptosis and glycoprotein Ibα ectodomain shedding. Platelets 2010;21:229-37.
24. Wang Z, Li S, Shi Q, Yan R, Liu G, Dai K. Calmodulin antagonists induce platelet apoptosis. Thrombosis Research 2010;125:340-50.
25. Li G, Qu L, Meng G, Bai X, Dai K, Zheng X. Crystallization and preliminary X-ray crystallographic studies of human FAIM protein. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010;66(Pt 8):935-7.
26. Yuan Y, Zhang W, Yan R, Liao Y, Zhao L, Ruan C, Du X, Dai K. Identification of a novel 14-3-3ζ binding site within the cytoplasmic domain of platelet glycoprotein Iba that plays a key role in regulating the VWF binding function of glycoprotein Ib-IX. Circulation Research 2009;105:1177-85.
27. Dai K, Wang Y, Yan R, Shi Q, Wang Z, Yuan Y, Cheng H, Li S, Fan Y, Zhuang F. Effects of microgravity and hypergravity on platelet function. Thrombosis and Haemostasis 2009;101:902-10. （Cover, Editorial focus）
28. Cheng H, Yan R, Li S, Yuan Y, Liu J, Ruan C, Dai K. Shear-induced von Willebrand factor-dependent platelet glycoprotein Ibα shedding. The American Journal of Physiology-Heart and Circulatory Physiology 2009;297:H2128-35.
29. Yan R, Wang Z, Yuan Y, Cheng H, Dai K. Role of cAMP-dependent protein kinase in the regulation of platelet procoagulant activity. Archives of Biochemistry and Biophysics 2009;485:41-8.
30. Yan R, Li S, Dai K. The critical roles for cyclic AMP/cyclic AMP-dependent protein kinase in platelet physiology. Frontiers of Biology in China, 2009;4:7-14.
31. Dai K, Yan R, Li S, Fan Y, Zhuang F, Ruan C. Prolonged inhibition of protein kinase A results in the dysfunction of platelet by GPIba shedding. Thrombosis Research 2009;124:101-9.
32. Li G, Tang Z, Meng G, Dai K, Zhao J, Zheng X. Crystallization and preliminary X-ray crystallographic studies of O-methyltransferase from Anabaena PCC 7120. Acta Cryst Structural Biology and Crystallization Communications 2009; F65:1039-41.
33. Li S, Shi Q, Wang Z, Yan R, Cheng H, Dai K. Hypergravity Results in Human Platelet Hyperactivity. Journal of Physiology and Biochemistry 2009;65:147-56.
34. Dai K, Bodnar R, Berndt MC, Du X. A critical role for 14-3-3 protein in platelet adhesion and its therapeutic implications. Blood 2005; 106:1975-81.
35. Dai K, Zhu H, Ruan C. Generation and characterization of recombinant single chain Fv antibody that recognizes platelet glycoprotein Ibalpha. Thrombosis Research 2003;109:137-44.
36. Dai K, Gao W, Ruan C. The Sma I polymorphism in the von Willebrand factor gene associated with acute ischemic stroke. Thrombosis Research 2001;104:389-95.
Professional Memberships:
Member, International Academy of Astronautics
Chairman, Professional Committee of Microcirculation, Chinese Association of Integrative Medicine
Council Member, Chinese Society of Thrombosis and Homeostasis
Deputy Director, Group of Vascular Biology, Professional Committee of Hematology, Chinese Association of Pathophysiology
Council Member, China society of microcirculation